Fireworks can be thought of more in terms of a program such as InDesign. InDesign creates print layouts, and Fireworks creates screen layouts. Photoshop and Illustrator should be used only as a supplier. You create graphics in Photoshop and Illustrator to be brought into Fireworks to create a screen design.
The following video demonstrates some of the most important features that make Fireworks the best layout tool for screen design.