Create high-performance Windows, Mac, Linux, iOS, Android, webOS, Flash and HTML5 apps
NME is proving to be a great framework on top of haxe to use for multi-platform development. Currently learning the ins and outs of it by porting my CoronaSDK game to the language and platform.
Blog post will be coming showing my setup and how to get started so be on the lookout. Till then if you are at all doing Flash dev and want a more optimized platform for multi-platform development you should start checking this out.
Here are the bullet points of you should look at using to get started.